1850 Atlas
| Name | What | Place | Pop | Other |
| Southampton | PT | Hampshire Co, MA | 1,067 | water by Manhan river |
| Southampton | PT | Somerset Co, PA | 1,326 | |
| Southampton | PT | Bucks Co, PA | 1,416 | water by Poquessing & Pennyback creeks |
| Southampton | PT | Cumberland Co, PA | 1,651 | |
| Southampton | PT | Franklin Co, PA | 1,795 | water by Conedogwinit creek & Mean's run |
| Southampton | PT | Bedford Co, PA | 1,347 | |
| Southampton | T | Trumbull Co, OH | 1,013 | |
| Southampton | PO | Peoria Co, IL | ||
| Southborough | PT | Worcester Co, MA | 1,347 | water by a tributary of Sudbury river |
| Southbridge | PT | Worcester Co, MA | 2,824 | water by Quinnebaug river |
| Southbury | PT | New Haven Co, CT | 1,484 | water by Pamperaug river |
| Southerland | PO | Jefferson Co, FL | ||
| Southerland Springs | PO | Bexar Co, TN | ||
| Southfield | PT | Richmond Co, Staten Island, NY | 2,709 | water by New York bay |
| Southfield | PT | Oakland Co, MI | 1,658 | water by north branch of Ronge river |
| Southfield | PO | Berkshire Co, MA | ||
| Southford | PV | New Haven, CT | ||
| Southington | PT | Hartford Co, CT | 2,135 | water by Quinnipiak river |
| Southington | PT | Trumbull Co, OH | 1,013 | |
| Southold | PT | Suffolk Co, Long Island, NY | 4,723 | water by Long Island sound, Great Peconic & Gardiner's bays |
| Southport | PT | Chemung Co, NY | 3,184 | water by Chemung river |
| Southport | PV | Fairfield twp, Fairfield Co, CT | water by Mill river & Long Island sound | |
| Southport | V | Racine CO, WI | ||
| Southport | PO | Marion Co, IN | ||
| Southport | PO | Lincoln Co, ME | ||
| Southville | PO | Stockholm twp, St Lawrence Co, NY | ||
| Southville | PV | Shelby Co, KY | ||
| Southville | PO | Litchfield Co, CT | ||
| Southwest Harbor | PV | HancockCo, ME | ||
| Southwest Oswego | PO | Oswego Co, NY | ||
| Southwick | PT | Hampden Co, MA | 1,120 | water by tributary of Westfield river |
| Sowardtown | PV | Kent Co, DE | ||
| Soxville | PT | Monroe Co, PA | ||
| Spadra | PT | Johnson Co, AR | 1,209 | |
| Spafford | PT | Onondaga Co, NY | 1,903 | water by Skaneateles & Otisco lakes |
| Spaford Hollow | PO | Spafford twp, Onondaga Co, NY | ||
| Spanish Prairie | PO | Crawford Co, MO | ||
| Spangsville | PO | Berks Co, PA | ||
| Sparta | PT | Livingston Co, NY | 1,372 | water by Canseraga creek |
| Sparta | PV | Hardiston twp, Sussex Co, NJ | 1,919 | |
| Sparta | PO | Morris twp, Washington Co, PA | ||
| Sparta | T | Westmoreland Co, PA | 1,719 | |
| Sparta | PV | Bloomfield twp, Morrow Co, OH | 127 | |
| Sparta | PO | Caroline Co, VA | ||
| Sparta | PV | Edgecomb Co, NC | ||
| Sparta | PV, CH | Hancock Co, GA | seat of justice | |
| Sparta | PV, CH | Conecuh Co, AL | seat of justice, water by Murder creek | |
| Sparta | PV, CH | White Co, TN | seat of justice, water by tributary of Caney fork of Cumberland river | |
| Sparta | PO | Randolph Co, IL | ||
| Sparta | PV, CH | Buchanan Co, MO | seat of justice, water by head waters of Bee creek | |
| Sparta | PO | Chickasaw Co, MS | ||
| Sparta | PO | Dearborn Co, IN | ||
| Sparta | T | Noble Co, IN | ||
| Sparta | PO | Bienville parish, LA | ||
| Sparta | PO | Hillsdale Co, MI | ||
| Sparta Centre | PO | Kent Co, MI | ||
| Spartanburgh | PV, CH | Spartanburgh dist, SC | seat of justice | |
| Spartanburgh | PV | Randolph Co, IN | ||
| Spartansburgh | PO | Crawford Co, PA | ||
| Spartapolis | PV | Rockingham Co, VA | ||
| Spear's Store | PO | Union parish, LA | ||
| Speedsville | PV | Caroline twp, Tompkins Co, NY | water by West Owego creek | |
| Speedwell | PO | Wythe Co, VA | ||
| Speedwell | PV | Barnwell dist, SC | water by Savannah river | |
| Speedwell | PV | Claiborne Co, TN | ||
| Speer's Landing | PO | Shelby Co, TN | ||
| Speersville | PO | Fulton Co, PA | ||
| Speight's Bridge | PV | Greene Co, NC | water by Mocassin creek | |
| Speir's Turnout | PO | Jefferson Co, GA | ||
| Spencer | PT | Worcester Co, MA | 2,244 | water by Seven Mile river |
| Spencer | PT | Tioga Co, NY | 1,782 | water by Cattotong creek |
| Spencer | PV | Davidson Co, NC | ||
| Spencer | PT | Medina Co, OH | 1,336 | |
| Spencer | PT | Guernsey Co, OH | 1,847 | water by head waters of Willis creek |
| Spencer | PV, CH | Van Buren Co, TN | seat of justice | |
| Spencer | PV, CH | Owen Co, IN | seat of justice, water by north fork of White river | |
| Spencer | PT | Pike Co, MO | ||
| Spencer | PT | Ralls Co, MO | ||
| Spencerport | PV | Ogden twp, Monroe Co, NY | on the Erie canal | |
| Spencerburgh | PV | Pike Co, MO | ||
| Spencertown | PO | Austerlitz twp, Columbia Co, NY | ||
| Spencerville | PO | De Kalb Co, IN | ||
| Spencerville | PO | Marengo Co, AL | ||
| Speonk | PO | South Hampton twp, Suffolk Co, Long Island, NY | ||
| Sperryville | PV | Rappahannock Co, VA | ||
| Spiceland | PO | Henry Co, IN | ||
| Spinnerstown | PV | Bucks Co, PA | ||
| Splice Creek | PO | Moniteau Co, MO | ||
| Splung | PO | Monroe Co, MS | ||
| Sporting Hill | PO | Lancaster Co, PA | ||
| Spottedville | PV | Stafford Co, VA | ||
| Spottswood | PV | Amboy twp, Middlesex Co, NJ | ||
| Spottsylvanis | PV, CH | Spottsylvania Co, VA | seat of justice, water by Po river | |
| Spout Spring | PO | Appomattox, Co, VA | ||
| Sprague's Falls | PO | Washington Co, ME | ||
| Spragueville | PO | Jackson Co, IA | ||
| Spraker's Basin | PV | Root twp, Montgomery Co, NY | on Erie canal | |
| Spread Eagle | PV | Radnor twp, Delaware Co, PA | ||
| Spread Oak | PO | Jefferson Co, GA |