1850 Atlas
| Name | What | Place | Pop | Other |
| Sprout Brook | PO | Montgomery Co, NY | ||
| Sprout Creek | PO | La Grange twp, Dutchess Co, NY | ||
| Spruce | PO | Bates Co, MO | ||
| Spruce Grove | PO | Monroe Co, PA | ||
| Spruce Hill | PO | Highland Co, VA | ||
| Spruce Hill | PO | Juniata Co, PA | ||
| Squam | V | Gloucester twp, Essex Co, MA | ||
| Squam Village | PV | Ocean Co, NJ | ||
| Squankum | PV | Howell twp, Ocean Co, NJ | ||
| Square Pond | PO | Tolland Co, CT | ||
| Squaw Betty | PO | Bristol Co, MA | ||
| Staatsburgh | PO | Hyde Park twp, Dutchess Co, NY | ||
| Stafford | PO | Tolland Co, CT | water by Furnace & Willimantic river | |
| Stafford | PT | Genesee Co, NY | 1,195 | water by Allen's & Black creeks |
| Stafford | PT | Ocean Co, NJ | 1,384 | water by Cedar & Manahawkin creeks |
| Stafford | PO | Monroe Co, OH | ||
| Stafford | PV, CH | Stafford Co, VA | seat of justice, water by Rappahannock river | |
| Stafford Springs | PV | Stafford twp, Tolland Co, CT | celebrated for its salubrious mineral springs | |
| Staffordville | PO | Stafford twp, Tolland Co, CT | ||
| Stagville | PV | Orange Co, NC | ||
| Stahlstown | PO | Westmoreland Co, PA | ||
| Stamford | PT | Bennington Co, VT | 833 | water by tributaries of Hoosic & Deerfield rivers |
| Stamford | PT | Fairfield Co, CT | 5,000 | water by Long Island sound, Mill & Miannus rivers |
| Stamford | PT | Delaware Co, NY | 1,708 | water by head waters of Delaware river |
| Stamper's Creek | T | Orange Co, IN | 777 | |
| Stamping Ground | PO | Scott Co, KY | ||
| Stanardsville | PV | Orange Co, VA | ||
| Stanardsville | PO | Carroll Co, TN | ||
| Standing Rock | PO | Stewart Co, TN | ||
| Standing Stone | PO | Bradford Co, PA | ||
| Standish | PT | Cumberland Co, ME | 2,290 | water by Sebago lake |
| Stanford | PT | Dutchess Co, NY | 2,158 | water by Wappiger's creek |
| Stanford | PV, CH | Lincoln Co, KY | seat of justice, water by tributary of Dick's river | |
| Stanford | PV | Monroe Co, IN | ||
| Stanfordville | PV | Stanford twp, Dutchess Co, NY | water by Wappinger's creek | |
| Stanfordville | PV | Putnam Co, GA | ||
| Stanhope | PV | Sussex Co, NJ | water by Musconetcong river & Morris canal | |
| Stanhope | PV | Monroe Co, PA | ||
| Stanhope | PV | Nash Co, NC | ||
| Stanley Corners | PO | Ontario Co, NY | ||
| Stanton | PO | Hunterdon Co, NJ | ||
| Stanton | PO | Bracken Co, KY | ||
| Stanton | PO | Newcastle Co, DE | ||
| Stantonsburgh | PV | Edgecombe Co, NC | ||
| Stantonville | PV | Anderson dist, SC | ||
| Stantonville | PO | McNairy Co, TN | ||
| Stantonville | PO | Calumet Co, WI | ||
| Stanwich | PO | Fairfield Co, CT | ||
| Stanwix | PO | Oneida Co, NY | ||
| Staples Rancho | PO | Calaveras Co, CA | ||
| Stapleton | PV | Southfield twp, Richmond Co, Staten Island, NY | water by New York harbor | |
| Stapleton | PO | Amherst Co, VA | ||
| Star | PO | Assumption parish, LA | ||
| Star | PO | Walker Co, TX | ||
| Starfield | PO | Peoria Co, IL | ||
| Star Furnace | PO | Carter Co, KY | ||
| Stark | PT | Somerset Co, ME | 1,446 | water by Sandy & Kennebec rivers |
| Stark | PT | Coos Co, NH | 418 | |
| Stark | PT | Herkimer Co, NY | 1,243 | water by Otsquaga creek |
| Starkey | PT | Yates Co, NY | 2,675 | water by Seneca lake |
| Starksborough | PT | Addison Co, VT | 1,400 | water by Huntingdon river & Lewis creek |
| Starkville | PV | Stark twp, Herkimer Co, NY | ||
| Starkville | V | Hoosick twp, Rensselaer Co, NY | water by Walloomsack creek | |
| Starkville | PV, CH | Lee Co, GA | seat of justice, water by tributary of Flint river | |
| Starkville | PV, CH | Oktibbeha Co, MS | seat of justice | |
| Starlington | PO | Butler Co, AL | ||
| Starr | PT | Hocking Co, OH | 1,045 | water by head waters of Raccoon creek |
| Starrsville | PV | Newton Co, GA | ||
| Starucca | PV | Wayne CO, PA | ||
| State Bridge | PO | Lenox twp, Madison Co, NY | ||
| Stateburgh | PV, CH | Sumter dist, SC | seat of justice | |
| State Line | PO | Franklin Co, PA | ||
| State Line | PO | Trumbull Co, OH | ||
| State Line | PO | McHenry Co, IL | ||
| State Line | PO | Walworth Co, WI | ||
| State Rights | PO | Oglethorpe Co, GA | ||
| State Road | PO | Lycoming Co, PA | ||
| Statesborough | PV, CH | Bullock Co, GA | seat of justice | |
| Statesvile | PV, CH | Iredell Co, NC | seat of justice | |
| Statesville | PV | Wilson Co, TN | ||
| Station | PO | Thomas Co, GA | ||
| Staunton | PV, CH | Augusta Co, VA | seat of justice, water by Lewis creek | |
| Staunton | PV | Granville Co, NC | ||
| Staunton | PT | Miami Co, OH | 1,475 | |
| Staunton | PV | Macoupin Co, IL | water by head waters of Silver creek | |
| Staunton | PO | Fayette Co, OH | ||
| Steady Run | PO | Keokuk Co, IA | ||
| Steam Factory | PO | Muscogee Co, GA | ||
| Steam Mill | PO | Warren Co, PA | ||
| Steamport | PO | Henderson Co, KY | ||
| Steedman's | PO | Lexington dist, SC | ||
| Steele Creek | PO | Mecklenburgh Co, NC | ||
| Steele's | PO | Anderson dist, SC | ||
| Steele's | PO | Rush Co, IN | ||
| Steele's Landing | PO | Ottawa Co, MI | ||
| Steele's Mills | PO | Randolph Co, IL | ||
| Steele's Tavern | PO | Augusta Co, VA | ||
| Steeleville | PV | Chester Co, PA | ||
| Steelsville | PV, CH | Crawford Co, MO | seat of justice, water by Maramec river | |
| Steen's Creek | PO | Rankin Co, MS | ||
| Steep Bottom | PO | Beaufort dist, SC | ||
| Steep's Falls | PO | Cumberland Co, ME | ||
| Steer Creek | PO | Gilmer Co, VA | ||
| Stembersville | PO | Carbon Co, PA | ||
| Stephensburgh | PO | Hardin Co, KY | ||
| Stephen's Challenge | PO | Bledsoe Co, TN | ||
| Stephenson's Depot | PO | Frederick Co, VA | ||
| Stephensport | PV | Breckenridge Co, KY | ||
| Stephentown | PT | Rensselaer Co, NY | 2,622 | water by Kinderhook river |
| Stephensville | PO | Wilkinson Co, GA | ||
| Stepney | PV | Monroe twp, Fairfield Co, CT | ||
| Stepney Depot | PO | Fairfield Co, CT | ||
| Sterling | PT | Lamoille Co, VT | 233 | water by tributaries of Lamoille & Onion rivers |
| Sterling | PT | Worcester Co, MA | 1,805 | water by Still river |
| Sterling | PT | Windham Co, CT | 1,025 | water by tributaries of Noosup river |
| Sterling | PT | Cayuga Co, NY | 2,808 | water by Sodus creek & Lake Ontario |
| Sterling | T | Brown Co, OH | 981 | |
| Sterling | T | Macomb Co, MI | 876 | |
| Sterling | PT | Wayne Co, PA | 1,033 | water by Waullenpaupack creek & Lehigh river |
| Sterling | PO | Montgomery Co, GA | ||
| Sterling | PO | Whitesides Co, IL | ||
| Sterling | PO | Philips Co, AR | ||
| Sterling | PO | Crawford Co, IN | ||
| Sterling Bottom | PO | Meigs Co, OH | ||
| Sterling Grove | PO | Greenville dist, SC | ||
| Sterling Hill | PO | Windham Co, CT | ||
| Sterlington | PO | Crawford Co, PA | ||
| Sterlingville | PO | Wyoming Co, PA | ||
| Sterlingville | PV | Philadelphia twp, Jefferson Co, NY | water by tributary of Indian river | |
| Sterretania | PO | Erie Co, PA | ||
| Stetson | PT | Penobscot Co, ME | 885 | water by tributaries of Sebasticook & Sowadabscokk rivers |